Indian Journal of Advances in Chemical Science, Volume: 10, Issue : 3, August 2022

ISSN No.: 2320-0898 (Print); 2320-0928 (Electronic)

DOI: 10.22607/IJACS.2022.1003004

Research Article

Synthesis of Acetylsalicylic Acid from Salicylic Acid and Acetic Anhydride, Using Phosphoric Acid as Catalyst

Emily Augusto da Conceição, Gleyton Pinto Lisboa, Jennifer Santos Rosa, Lívia Mara Ribeiro Gaspar, Luiza Crispim, Andréa Cristina de Oliveira Sá, Sara Nállia de Oliveira Costa*

ABSTRACT

Acetylsalicylic acid (ASA) is known worldwide as the active substance in the ASA drug, with antipyretic, anti-inflammatory, and analgesic activities. For many years, researchers have been improving the formulation of this medicine, craving reduce you effects collateral effects on organisms and remove the characteristic bitter taste. To attend the demand, the aspirin needed to be produced in scale industrial, being necessary to use alternative raw material. Therefore, in this work, we aimed to synthesize the acetylsalicylic acid (aspirin) from salicylic acid and anhydrous acetic acid, using phosphoric acid as a catalyst. As well as purifying the final product using the recrystallization technique. With the methodology carried out, it was possible to obtain, through the acetylation reaction, the synthesis of the acid acetylsalicylic, and an weight in aspirin in 2.5128 g. The same was purified using the technique of recrystallization and it was obtained an income in 48.16%. This result demonstrates loss of product; however, it did not make the formation of the product desired by reaction of acetylation.

Key words: Salicylic acid, Acetylsalicylic acid, Aspirin.

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