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Indian Journal of Advances in Chemical Science, Volume: 10,
Issue : 4, December 2022 |
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ISSN No.: 2320-0898 (Print);
2320-0928 (Electronic)
DOI: 10.22607/IJACS.2022.1004007 |
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Research Article
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2-Pyrrolidin-2yl-1H-benzimidazole (PBI): An efficient
organocatalyzed synthesis of β-sulphido carbonyl compounds |
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Gaurav Praksh, Ajay Kumar Das
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ABSTRACT |
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An efficient and organocatalytic synthetic protocol has been
developed involving 2-Pyrrolidin-2yl-1H-benzimidazole (PBI)
catalyzed synthesis of β-sulfido carbonyl compounds through reaction
of thiophenols with α,β-unsaturated carbonyl compounds in good and
excellent yield under mild reaction conditions. The synthetic
process for PBI organocatalyst has also been developed. The
synthesized organocatalyst was further employed for the synthesis of
β-sulfido carbonyl compounds using α,β-unsaturated carbonyl
compounds as substrates. We investigated the appropriated reaction
condition by screening different solvents and conditions. The
optimized reaction conditions further utilized to generate the
library of β-sulfido analogues. All the synthesized analogs were
characterized using spectroscopic and spectrometric techniques. |
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Key words: 2-Pyrrolidin-2yl-1H-benzimidazole, Conjugate
addition, Thio-Michael reaction, Organocatalysis. |
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[Download Full Article
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