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Polymeric drug delivery systems (DDS)
were developed to increase half-life and bioavailability, making
them ideal for biocompatible targeted drug delivery. Hence, instead
of using traditional treatment methods such as surgery,
chemotherapy, and radiation, polymeric therapeutics have been used
to reduce adverse effects. To address this need, the present work
develops the potential natural bionanocomopsite from reduced
graphene oxide, carboxymethyl chitosan, and sodium alginate DDS by
the facile gelation technique for the targeted delivery of two
anti-cancer drugs (5-fluorouracil and doxorubicin). These
bionanocomposites are characterized by the Fourier-transform
infrared spectroscopy, X-ray diffraction, differential scanning
calorimetry, thermogravimetric analysis, and scanning electron
microscopic, further evaluated the drug loading and entrapment
efficiency. The in vitro drug release characteristics of drugs were
performed in pH 1.2 and 7.4 at 37°C. In vitro cytotoxicity
experiments of bionanocomposites against MCF-7 (breast cancer cell
line), results indicate that the highest rate of cancer cell death
occurred compared to pure doxorubicin. This research not only
provides rationale for enhancing a DDS tailored to MCF-7, but also
suggests that DOX-rGO may be a potential therapeutic delivery
vehicle.
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Key words: Doxorubicin, Graphene oxide, Chitosan, Sodium
Alginate, pH responsive polymers, Anti-cancer. |
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