H₂O₂:HCl Catalyzed Simple and Efficient Synthesis of 3-Methyl-4-Arylmethylene Isoxazol-5(4H)-One in Aqueous Medium

DOI: 10.22607/IJACS.2025.1301003

Research Article

ABSTRACT

A simple and efficient method for the synthesis of 3-methyl-4-arylmethylene isoxazol-5(4H)-one has been accomplished through Knoevenagel condensation using various aromatic aldehyde, ethyl acetoacetate, and hydroxylamine hydrochloride with H2O2:HCl in aqueous medium. In this methodology, H2O2:HCl used as catalyst and water as green reaction solvent, which gives one-pot synthesis of 3-methyl-4-arylmethylene isoxazol-5(4H)-one with excellent yields (88–93%). All products were characterized by using 1H NMR, 13C NMR, Fourier transform infrared spectroscopy, and mass spectrometry.

Key words:  3-methyl-4-arylmethylene isoxazol-5(4H)-one, H2O2:HCl catalyst system, Hypochlorous acid, Knoevenagel condensation, Water.
 

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Indian Journal of Advances in Chemical Science,

Volume: 13, Issue : 1,  January 2025

ISSN No.: 2320-0898 (Print); 2320-0928 (Electronic)