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Hydrogels are
emerging as innovative materials in biomedicine due to their unique
physicochemical properties, biocompatibility, and versatility. This
review focuses on the development and applications of polymeric
hydrogel matrices and silver nanocomposites,
emphasizing their role in controlled drug delivery and antimicrobial
applications. Polymeric hydrogels derived from natural polymers,
such as sesbania gum, hyaluronic acid, and carboxymethyl chitosan,
alongside synthetic polymers, such as poly(vinyl alcohol), are
highlighted for their ability to achieve sustained and targeted drug
delivery. These materials provide a promising platform for
delivering bioactive molecules, particularly chemotherapeutic
agents, such as doxorubicin, with reduced systemic toxicity and
enhanced therapeutic outcomes. The review also delves into the
integration of silver nanoparticles within hydrogels, a strategy
that imparts robust antimicrobial properties, making these
composites highly effective for wound healing applications.
Synthesis methodologies, including chemical cross-linking and
environmentally friendly green techniques are discussed in detail,
providing insights into their influence on the structural and
functional properties of the hydrogels. In addition, the article
explores the potential of stimuli-responsive hydrogels, capable of
responding to environmental triggers, such as pH, temperature, and
ionic strength, for precise and controlled drug release. Recent
advances in these hydrogel systems are examined, showcasing their
applications in cancer therapy, wound healing, and infection
management. The review further identifies existing challenges, such
as scalability and regulatory hurdles, while proposing future
research directions to enhance the efficacy and commercial viability
of these systems. Ultimately, this article consolidates the present
state of research and underscores the transformative potential of
hydrogel-based platforms in advancing personalized medicine and
improving patient outcomes. |
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Key words: Antimicrobial applications, Biocompatible
materials, Biomedical applications, Cancer therapy, Controlled drug
delivery, Doxorubicin, Green synthesis, Nanoparticle integration,
Polymeric hydrogels, Silver nanocomposites, Stimuli-responsive
hydrogels, Sustained drug release.
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Indian Journal of Advances in Chemical Science,
Volume: 13, Issue : 1, January 2025
ISSN No.: 2320-0898 (Print);
2320-0928 (Electronic) |
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