Synthesis of 4-Aminoantipyrine Derivatives: A Rapid and Eco-Friendly Approach

DOI: 10.22607/IJACS.2025.1302002

Research Article

ABSTRACT

This study presents an eco-friendly and efficient method for synthesizing 4-aminoantipyrine derivatives through a reaction with aldehydes. Ethanol is employed as a co-solvent, ensuring a sustainable medium, while N,N-dimethylethanolamine acts as a bifunctional organic catalyst, enhancing reaction efficiency. The reaction proceeds efficiently at ambient temperature, thereby minimizing energy usage. This method offers high yields in a short time, making it both cost-effective and practical. The synthesized derivatives were characterized using various spectroscopic techniques to confirm their structural integrity and purity. This green synthetic approach minimizes the use of hazardous reagents and aligns with sustainable chemistry principles, demonstrating its potential for environmentally benign organic transformations.
 

Key words: Antiangiogenic activity, Antimicrobial, Metal complexes, Photocatalytic, Schiff base.

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Indian Journal of Advances in Chemical Science,

Volume: 13, Issue : 2,  January 2025

ISSN No.: 2320-0898 (Print); 2320-0928 (Electronic)