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Sustainable Synthesis
of Quinazolinone Scaffolds in Aqueous Media: A Surfactant-Promoted
Approach |
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DOI: 10.22607/IJACS.2025.1302003 |
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Research Article
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Pratyoosh Kumar, Vishwa Deepak
Tripathi* |
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ABSTRACT |
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A versatile and
green synthetic protocol has been developed for the synthesis of
substituted quinazolinone and spiroquinazolinone heterocycles
effectively through a combined surfactant-mediated system. The use
of surfactant, water as reaction medium, room temperature, high
yield, and ease of purification made the process very effective and
eco-friendly in nature. To demonstrate the wide scope of the
reaction, isatoic anhydride and isatin are used as reactants in
different sets of reactions that lead to the formation of
quinazolinones and spiroquinazolinones. A total of 12 derivatives
have been prepared and characterized by all the spectroscopic data.
The developed protocol presents a better and environmentally
efficient methodology to get these heterocycles.
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Key words: Aqueous, Heterocyclic, Quinazolinones,
Surfactant, Sustainable chemistry. |
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[Download Full Article
PDF] |
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Indian Journal of Advances in Chemical Science,
Volume: 13, Issue : 2, January 2025
ISSN No.: 2320-0898 (Print);
2320-0928 (Electronic) |
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