Indian Journal of Advances in Chemical Science Volume: 7, Issue 1: , January 2019

ISSN No.: 2320-0898 (Print); 2320-0928 (Electronic)

DOI: 10.22607/IJACS.2018.701001

Review Article

Synthesis, Crystal Structure Refinement, and Morphological Study of Bioactive Material: Strontium and Iron-Substituted Nano-Hydroxyapatite: Ca10-xMx(PO4)6(OH)2 (M=Sr and Fe and 0 ≤ x ≤ 0.1)

O. P. Shrivastava*, Ramesh C. Deka, Rashmi Chourasia and Rasnadevi

ABSTRACT

Nano-hydroxyapatite (HA) is a bioactive and important material well known for several applications. Rietveld refinement and structural analysis of X-ray powder diffraction patterns have been investigated to understand the effect of Sr and Fe substitution on the structural properties of bioactive material Ca10-xMx(PO4)6(OH)2 or Ca5−xMx(PO4)3(OH) where M=Sr and Fe and x=0.05). The crystal chemistry of Sr- and Fe-substituted HA phases has been investigated using General Structure Analysis System programming. Sr- and Fe-substituted HA phases crystallize in the space group P 63/m; Z=2. Powder diffraction data have been subjected to Rietveld refinement to arrive at a satisfactory structural convergence of R-factors. The expected overall decrease of the lattice constants in the samples is explained in terms of local lattice distortions. The unit cell volume and polyhedral distortion increase with a rise in the size of loaded cation in the HA matrix. Scanning electron microscopy, transmission electron microscopy, and energy-dispersive X-ray analysis provide evidence of Sr and Fe in the HA matrix.

Key words: Bioactive nanomaterial, Hydroxyapatite, X-ray diffraction, General structure analysis system, Structure refinement, Fourier transform infrared, Scanning and transmission electron microscopy.

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