Indian Journal of Advances in Chemical Science Volume: 7, Issue 2: , April 2019

ISSN No.: 2320-0898 (Print); 2320-0928 (Electronic)

DOI: 10.22607/IJACS.2018.702004

Research Article

Design, Synthesis, and Biological Evaluation of Benzothiazole Chalcone Conjugates as Antitumor Agents

Bobburi Nagaseshadri*, Avuguddi Ramesh Babu, Pathivada Naveen

ABSTRACT

A series of novel benzothiazole chalcone conjugates (12a-j) have been designed and synthesized by a simple, six-step synthetic procedure. Benzothiazole chalcone conjugates were synthesized by the Claisen-Schmidt condensation of various substituted acetophenones with substituted benzothiazole aldehydes. The structures of final compounds were characterized by infrared, nuclear magnetic resonance, and electrospray ionization mass spectrums. Furthermore, all the benzothiazole chalcone conjugates have been evaluated at the National Cancer Institute USA for their antitumor activity at a single dose (1×10−5 M), on a panel of 60 human tumor cell lines. From the screening result, it has been observed that compound 12e exhibited promising antitumor activity.

Key words: Benzothiazole, Chalcone, Antitumor activity, Anticancer activity.

[Download Full Article PDF]