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Indian Journal of Advances in Chemical Science, Volume: 9,
Issue : 3, August 2021 |
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ISSN No.: 2320-0898 (Print);
2320-0928 (Electronic)
DOI: 10.22607/IJACS.2021.903010 |
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Research Article
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Synthesis, Characterization and Biological Evaluation of 1,3-Bis(5-
Hydantoinyloxy) Benzenes |
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Ramesh G. Surose*, V. N. Ingle, L. J.
Paliwal |
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ABSTRACT |
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An efficient and straightforward
two-step approach toward 1,3-bis(5-hydantoinyloxy)benzenes was
developed. A hydantoin is reacted with bromine to produce
5-bromohydantoin, which on reaction with the resorcinol’s to produce
corresponding 1,3-bis(5-hydantoinyloxy)benzenes in the presence of K2CO3
in dioxane. The structures of newly synthesized compounds have been
reputable on the basis of their spectral data. Their biological
activities against Gram +ve and Gram −ve bacteria are reported. |
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Key words: Hydantoin, Bis-hydantoin,
Anticonvulsant, Resorcinol. |
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[Download Full Article
PDF] |
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