Indian Journal of Advances in Chemical Science, Volume: 9, Issue : 4, December 2021

ISSN No.: 2320-0898 (Print); 2320-0928 (Electronic)

DOI: 10.22607/IJACS.2021.904004

Thiazole Core: A Restorative Target in the Discovery of Potent Anti-cancer Agents

Yashab Fatima, Mahima S. Dayal, Tanvi S. Lal, Imran Ahmad*
 

ABSTRACT

In the past few decades, cancer has been one of the crucial health issues and protruding reason of deaths to humans. An appreciable advancement has been made in anti-cancer drugs development and various new anticancer agents that have natural as well as synthetic origin have been generated so far. Out of different heterocyclic compounds, thiazole which is 5-membered unique heterocyclic ring containing sulfur as well as nitrogen atoms has an eminent function in several medicinally significant organic compounds. Thiazole moiety has displayed several therapeutic actions which also include anticancer activities and has been an elementary part of clinically applied anticancer pharmaceutical drugs. Lately, majority of the compounds extracted from natural sources that contain thiazole component manifest significant cytotoxicities and showcase antitumor capabilities as well. In this background, variety of structural modifications has been made in the original structure, which includes the inclusion of variety of substituents or the incorporation with several other carbo- and also heterocycles, to elevate the antitumoral efficacy. Moreover, these thiazole compounds are less toxic and have been clinically proven to be highly effective and have excellent potency for anticancer activity. This review showcases the present phenomenal research on thiazoles and illuminates their biological significance in the discovery of anticancer drugs. The findings of this review article may help the researchers in the cogent design of anti-cancer drug molecules that are way more potent and bio-target specific in action.

Key words:   Heterocyclic compounds, Thiazole, Drug discovery, Cancerous cells, Anticancer agent
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