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In this study, synthesis and
pharmacological screening of various derivatives of 3-[4-(1H-4
methyl benzamidazol-2-yl)
2-hydroxy phenyl] -1-N-ethoxy phthalimido -5 (arylidene)-2-phenyl-
1,3-thiazolidin-4-one (5a-5d) were reported. These
compounds (5a-5d) were synthesized by reaction of corresponding
arylidene derivatives (4a-4d) with phthalimidoxy ethyl bromide in
presence of C2H5OH/pyridine, while these compounds (4a-4d) have been
synthesized by treating 3-[4-(1H-4methyl
benzimidazol-2-yl)-2-hydroxy phenyl] 2-phenyl-1,3 – thiazolidin-4one
with substituted aromatic aldehydes. The structure of newly
synthesized compounds was characterized by IR, 1H NMR, mass
spectroscopy, and elemental analysis. These compounds were screened
for their pharmacological activity, namely, anti-inflammatory
activity and antibacterial activity. |
