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Ferric dodecyl sulfonate (FDS)
[Fe(DS)3], a Lewis acid-surfactant-combined catalyst has been
successfully used for the synthesis of a library of
tetrahydro-β-carbolines (THBCs) through Pictet–Spengler reaction
under conventional heating reaction conditions in aqueous medium.
The merit of this protocol is the formation of FDS micellar spheres
in water, the ability of each individual sphere to host the
substrates to react easily, and efficiently to form the products in
short reaction times. Hence, the reaction of tryptamine with various
aldehydes has been facilitated the formation of desired THBCs in
good yields. The aqueous reaction medium, dual (hydrophilic and
hydrophobic) behavior of FDS catalyst, high yields of products, and
short reaction times had established this as an eco-friendly and
economical protocol for the synthesis of THBCs. |
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Key words: Pictet–Spengler
reaction, Ferric dodecyl sulfonate, Aqueous medium, Micellar sphere,
Tetrahydro-β-carbolines. |
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