Triflic Anhydride Mediated Synthesis of Weinreb Amides Derived from Nα-Protected Amino Acids
H. Keerthi*
DOI: 10.22607/IJACS.2023.1104004
Volume 11, Issue 4 | Pages: 240-246
Abstract
A facile, one-pot synthesis of aryl/Nα-protected aminoalkyl Weinreb amides from their corresponding carboxylic acid mediated by triflic anhydride (Tf2O) in the presence of Et3N has been described. Tf2O is utilized for the activation of carboxylic acid, followed by the reaction with N,O-dimethylhydroxylamine in CH2Cl2 to obtain the desired Weinreb amide in good yields. All the amides made were characterized by 1H NMR, 13C NMR, and HRMS.
Keywords
Weinreb amides N O-dimethylhydroxylamine Nα-Fmoc/Boc/Cbz-amino acid Triflic anhydrideReferences
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Citation
H. Keerthi*. Triflic Anhydride Mediated Synthesis of Weinreb Amides Derived from Nα-Protected Amino Acids. J Appl Pharm Sci. 2024; 11(4):240-246.