Synthesis of Substituted-(3-phenyl-1,2,4-oxadiazol-5yl)-methyl-9-chloro-2,3-dimethyl-6,7-dihydro-5H-benzocyclohepten-8-carboxylates
P. M. Gomedhika, N. J. P. Subhashini*
DOI: 10.22607/IJACS.2022.1001004
Volume 10, Issue 1 | Pages: 18-21
Abstract
A novel series of substituted-(3-phenyl-1,2,4-oxadiazol-5-yl)-methyl-9-chloro-2,3-dimethyl-6,7-dihydro-5H-benzocyclohepen-
8-carboxylates (5a-h) have been synthesised in satisfactory yields in presence of Caesium carbonate and dry N,N-dimethyl
formamide by reacting with the 9-chloro-2,3-dimethyl-6,7-dihydro-5H-benzocyclohepten-8-carboxlic acid (3) with various
phenyl-1,2,4-oxadiazoles (4a-h) for 8–10 h at room temperature and their structures were confirmed by 1H NMR, 13C NMR, IR
and Mass spectral analyses and they were good agreement with proposed structures
Keywords
Caesium carbonate N’-hydroxybenzamidines Phenyl-1 2 4-oxadiazoles Vilsmeier-Haack-Arnold reaction.References
No references available for this article.
Citation
P. M. Gomedhika, N. J. P. Subhashini*. Synthesis of Substituted-(3-phenyl-1,2,4-oxadiazol-5yl)-methyl-9-chloro-2,3-dimethyl-6,7-dihydro-5H-benzocyclohepten-8-carboxylates. J Appl Pharm Sci. 2022; 10(1):18-21.