Abstract

In this study, synthesis and pharmacological screening of various derivatives of 3-[4-(1H-4 methyl benzamidazol-2-yl)
2-hydroxy phenyl] -1-N-ethoxy phthalimido -5 (arylidene)-2-phenyl- 1,3-thiazolidin-4-one (5a-5d) were reported. These
compounds (5a-5d) were synthesized by reaction of corresponding arylidene derivatives (4a-4d) with phthalimidoxy
ethyl bromide in presence of C2H5OH/pyridine, while these compounds (4a-4d) have been synthesized by treating
3-[4-(1H-4methyl benzimidazol-2-yl)-2-hydroxy phenyl] 2-phenyl-1,3 – thiazolidin-4one with substituted aromatic
aldehydes. The structure of newly synthesized compounds was characterized by IR, 1H NMR, mass spectroscopy, and
elemental analysis. These compounds were screened for their pharmacological activity, namely, anti-inflammatory activity
and antibacterial activity.