Abstract

The pharmaceutical importance of spiro-imidazolidinedione derivatives is well established. Here, we communicate the synthesis
of new spiro [imidazolidine-pyrazoline]- 2,4-diones in two steps. The first step involves the preparation of 5-ary1idene
imidazolidine-2,4-dione derivatives by well-known Knoevenagel reaction involving condensation of aromatic aldehydes and
imidazolidine-2,4-dione. In the second step, reaction of diazomethane with 5-ary1idene imidazolidine-2, 4-dione resulted in
formation of new spiro [imidazolidine-pyrazoline] 2,4-dione derivatives. The synthesized spiro compounds were characterized
by spectral analysis. Computational studies have been utilized to explain the stability of tautomeric forms of synthesized
compounds. The Swiss ADME studies indicate suitable physiochemical properties, drug-likeliness features, and good oral
bioavailability.