A novel method for deoxygenation of sugar lactones: a practical route to synthesis of the key intermediates of the “Statins”
Naresh Vempala, A. Jaya Shree*
DOI: 10.22607/IJACS.2022.1004006
Volume 10, Issue 4 | Pages: 180-183
Abstract
A novel and alternate deoxygenation method for selective removal of a hydroxyl group in carbohydrates is described. The method
could be used as a synthetic tool to transform complex carbohydrates into desirable synthetic targets, particularly targets having
1,3-dihydroxy dispositions. The usefulness of this methodology is demonstrated in the preparation of a (2R, 5S)-dihydroxy hexanoic
acid ester which served as the precursor for generating the side chain of rosuvastatin calcium, a cholesterol lowering drug.
Keywords
Carbohydrates Deoxy sugars Statins Rosuvastatin calcium.References
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Citation
Naresh Vempala, A. Jaya Shree*. A novel method for deoxygenation of sugar lactones: a practical route to synthesis of the key intermediates of the “Statins”. J Appl Pharm Sci. 2023; 10(4):180-183.