Microwave-assisted Synthesis of Naphthyl Pyrimidinones and their Antioxidant Activity
Ajita Yadav, Shafia Mir, Praveen Kumar*, Ayaz Mahmood Dar
DOI: 10.22607/IJACS.2021.903018
Volume 9, Issue 3 | Pages: 214-217
Abstract
Microwave-assisted synthesis of naphthyl pyrimidinones (4-6) was successfully completed after reacting naphthyl
thiosemicarbazones (1-3) with ethyl cyanoacetate in the presence of neutral alumina (Al2O3) and few drops of piperidine under
solvent-free conditions. The characterization of compounds (4-6) was done by spectral (IR, 1H-NMR, 13C-NMR, and MS) and
analytical data. The new compounds were screened for antioxidant activity by DPPH radical scavenging assay, during which
compounds depicted moderate to good DPPH radical scavenging activity.
Keywords
Antioxidant activity Microwave synthesis Naphthyl pyrimidinones.References
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Citation
Ajita Yadav, Shafia Mir, Praveen Kumar*, Ayaz Mahmood Dar. Microwave-assisted Synthesis of Naphthyl Pyrimidinones and their Antioxidant Activity. J Appl Pharm Sci. 2021; 9(3):214-217.