Abstract

Hydrogels are among the favored biomaterials because of their biocompatibility and non-toxic properties. Hydrogels are known
as smart polymers or smart materials because they are sensitive to environmental stimuli. The fundamental feature of this
method is the ability to vary their mechanical properties, swelling capacity, hydrophilicity, bioactive molecules porousness,
etc., influenced by varied stimuli such as temperature, time, pH, electromagnetic wave, field, and biological factors. The
characterization studies of polyacrylamide (PAM) composite hydrogel disclosed that partial polyaniline chains have grafted
on the nitrogen atom of PAM. These are usually prepared by polymer crosslinking. In this review, we have focused on the field
of tissue engineering and biomedical applications of PAM hydrogel that has been used as controlled drug delivery systems in
various fields such as agricultural fields, prescription drugs, medical specialty, and cosmetic business.