Abstract

Schizophrenia is a psychical disorder with abnormality in social behavior and failure to understand what is real. Despite
considerable efforts that have been made from a lot of researchers, there are still delays in the diagnosis and treatment of
schizophrenia. Therefore, this study has been focused to investigate the expected association between the levels of antioxidant
agents (Vitamin E, Vitamin A, glutathione [GSH], and uric acid) and the risk of schizophrenia. Levels of these variables were
determined in sera of 60 patients with schizophrenia, and then, the variations in their levels were analyzed in comparison with
60 healthy volunteers to try to predict of occurrence and progression of disease. The results obtained showed a significant
decrease in the levels of Vitamin E, GSH, uric acid, and urea, in contrast to non-significant change in the levels of Vitamin A in
schizophrenic patients compared to the healthy group. Data analysis also revealed the presence of a valuable correlation between
most of variables in schizophrenic patients. Accordingly, it can be suggested that these variables may have a vital role and
prognostic value against schizophrenia. Furthermore, it can be suggested that vitamin supplementation, in particular Vitamin E,
may play a crucial role in the treatment of schizophrenia or reduce the risk of schizophrenia. The real mechanism responsible
for the variations in the levels of these parameters in patients with schizophrenia is unclear and requires additional evaluation
by further comprehensive studies.