Host-guest Inclusion Complexation of 3-(2-Napthyl)-D-Alanine with α- and β-Cyclodextrins Explored by Nuclear Magnetic Resonance, Fourier-transform Infrared, High-resolution Mass Spectrometry, Surface Tension, and Conductometric Studies
Binoy Chandra Saha, Subhadeep Saha, Raja Ghosh and Mahendra Nath Roy*
DOI: 10.22607/IJACS.2019.702001
Volume 7, Issue 2 | Pages: 39-45
Abstract
Host-guest inclusion complex formation of α-cyclodextrin (α-CYD) and β-CYD with 3-(2-Napthyl)-D-alanine has been
investigated. Physicochemical and spectroscopic experimental data offer sufficient evidence about stabilization, carry, and
regulatory release of the guest molecule. Surface tension and conductivity studies indicate 1:1 stoichiometry of the inclusion
complexes. 1H nuclear magnetic resonance and Fourier-transform infrared studies confirm the inclusion phenomena. The host-
guest interactions have been explained on the basis of hydrogen bonding, Van der Waals force, hydrophobic effect, electrostatic
force, and exceptional structural effect of host-guest molecules
Keywords
Inclusion complex Cyclodextrin 3-(2-Napthyl)-D-Alanine Spectroscopic investigation Physicochemical studies.References
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Citation
Binoy Chandra Saha, Subhadeep Saha, Raja Ghosh and Mahendra Nath Roy*. Host-guest Inclusion Complexation of 3-(2-Napthyl)-D-Alanine with α- and β-Cyclodextrins Explored by Nuclear Magnetic Resonance, Fourier-transform Infrared, High-resolution Mass Spectrometry, Surface Tension, and Conductometric Studies. J Appl Pharm Sci. 2019; 7(2):39-45.