Abstract

A series of novel benzothiazole chalcone conjugates (12a-j) have been designed and synthesized by a simple, six-step synthetic
procedure. Benzothiazole chalcone conjugates were synthesized by the Claisen-Schmidt condensation of various substituted
acetophenones with substituted benzothiazole aldehydes. The structures of final compounds were characterized by infrared,
nuclear magnetic resonance, and electrospray ionization mass spectrums. Furthermore, all the benzothiazole chalcone conjugates
have been evaluated at the National Cancer Institute USA for their antitumor activity at a single dose (1×10−5 M), on a panel of
60 human tumor cell lines. From the screening result, it has been observed that compound 12e exhibited promising antitumor
activity.