Investigation of Host–Guest Inclusion Complexes of a Neurotransmitter inside into α- and β-Cyclodextrins through Hydrophobic and Hydrophilic Interactions by Physicochemical Approach
Habibur Rahaman, Kalipada Sarkar, Mitali Kundu, Mahendra Nath Roy*
DOI: 10.22607/IJACS.2019.703005
Volume 7, Issue 3 | Pages: 94-105
Abstract
In the present work, the formation of inclusion complex of a neurotransmitter, phenylethanolamine with α-cyclodextrin
(α-CD) and β-CD (β-CD) was examined from volumetric, viscometric, and spectroscopic studies. The supramolecular interaction
between CD and phenylethanolamine has been characterized by volumetric and viscometric and spectral studies. However, the
stoichiometry of host–guest of the inclusion complexes was ascertained from Job’s plot calculation from ultraviolet–visible
spectroscopy. The association/binding constant of the formation of inclusion complex was calculated from Benesi–Hildebrand
equation. The infrared (IR) and 1H-NMR spectroscopy also support the formation of inclusion complexes and the probable
manner of inclusion was defined from 1H-NMR and two-dimensional Roesy NMR spectroscopies.
Keywords
Phenylethanolamine Job’s plot cyclodextrins Benesi–Hildebrand equation.References
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Citation
Habibur Rahaman, Kalipada Sarkar, Mitali Kundu, Mahendra Nath Roy*. Investigation of Host–Guest Inclusion Complexes of a Neurotransmitter inside into α- and β-Cyclodextrins through Hydrophobic and Hydrophilic Interactions by Physicochemical Approach. J Appl Pharm Sci. 2019; 7(3):94-105.