Abstract

Three simple, sensitive, and rapid spectrophotometric methods were developed for the estimation of esomeprazole magnesium
(ESM) trihydrate in pure and its commercial dosage forms. These methods were based on the formation of charge–transfer
reaction between the drug, an n-electron donor and p-acceptors, 2,3-dichloro-5, 6-dicyano-p-benzoquinone, chloranilic acid,
and 1-chloro-2,4-dinitrobenzene. The absorbance of the formed charge–transfer complexes was measured and utilized for the
determination of ESM in its pure and commercial dosage forms. The developed methods were evaluated in terms of standard
deviation, relative standard deviation, correlation coefficient, limit of detection, and limit of quantitation. Molar absorptivity
and Sandell’s sensitivity were calculated at the optimum experimental conditions. The validity of the proposed methods was
ascertained by recovery studies which indicated that the present methods can be successfully applied for the determination of
ESM in pure and commercial dosage forms.