Abstract

Two copper complexes of type [Cu(phen)(L-Ser)(Tsc)]NO3 (1), [Cu(bpy)(L-Ser)(Tsc)]NO3 (2) (L-ser = L-serine, Tsc =
Thiosemicarbazide, phen = 1,10-phenanthroline, and bpy = 2,2’-bipyridyl) have been synthesized and characterized by elemental
analyses, ultraviolet-visible, infrared, and electron paramagnetic resonance (EPR) spectral studies. Based on elemental analyses
and EPR studies confirm that two complexes have five coordinated geometry. DNA-binding properties of these metal complexes
were investigated using absorption spectroscopy, fluorescence spectroscopy, viscosity measurements, and cyclic voltammetry.
The binding ability of complexes differs in terms of binding constant; this may be attributed to difference in ligand coordinated
the metal center, complex 1 shows higher binding affinity than complex 2. Complexes 1 and 2 have good antibacterial and
antifungal activity on comparing with standard drugs.