Abstract

A simple and efficient method for the synthesis of 3-methyl-4-arylmethylene isoxazol-5(4H)-one has been accomplished through Knoevenagel condensation using various aromatic aldehyde, ethyl acetoacetate, and hydroxylamine hydrochloride with H2O2:HCl in aqueous medium. In this methodology, H2O2:HCl used as catalyst and water as green reaction solvent, which gives one-pot synthesis of 3-methyl-4-arylmethylene isoxazol-5(4H)-one with excellent yields (88–93%). All products were characterized by using 1H NMR, 13C NMR, Fourier transform infrared spectroscopy, and mass spectrometry.