Mixed ligand Copper(II) complexes of polyazole ligands with pendant arms amide and hydrazide – DNA binding activity
Ch. Himasekhar, M. S. Surendrababu*
DOI: 10.22607/IJACS.2018.603009
Volume 6, Issue 3 | Pages: 156-162
Abstract
New pyridyl tetrazole ligands 2-(5-(pyridin-2-yl)-1H-tetrazol-1-yl)acetamide (L1), 2-(5-(pyridin-2-yl)-2H-tetrazol-2-yl)acetamide
(L2), 2-(5-(pyridin-2-yl)-1H-tetrazol-1-yl)acetohydrazide (L3), and 2-(5-(pyridin-2-yl)-2H-tetrazol-2-yl)acetohydrazide (L4) have
been prepared. These ligands and phenanthroline have been coordinated with CuCl2.2H2O to furnish corresponding mixed complexes
[Cu(L1)(Phen)]-[Cu(L4)(Phen)]. Electron paramagnetic resonance spectra of all the copper complexes are characteristic of
square planar geometry, with nuclear hyperfine spin 3/2. DNA binding studies were carried using UV-Vis absorption spectroscopy.
Viscosity and thermal denature studies revealed that each of these complexes is avid binders of calf thymus DNA.
Keywords
Pyridyl-tetrazole Pendant arm Mixed ligand copper complexes DNA binding propertiesReferences
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Citation
Ch. Himasekhar, M. S. Surendrababu*. Mixed ligand Copper(II) complexes of polyazole ligands with pendant arms amide and hydrazide – DNA binding activity . J Appl Pharm Sci. 2018; 6(3):156-162.