Synthesis of Silver Nanocomposite Hydrogel from Lysozyme-Mediated Poly(acrylamide) for the Inactivation of Pathogenic Bacteria
G. Viswanatha Reddy, K. Madhusudana Rao, K. S. V. Krishna Rao*, Chang-Sik Ha*
DOI: 10.22607/IJACS.2018.603010
Volume 6, Issue 3 | Pages: 163-170
Abstract
A simple eco-friendly method involving the lysozyme (Lys)-mediated controllable synthesis of silver nanoparticles (AgNPs)
in poly(acrylamide) (PAAm) hydrogel networks is reported. The as-synthesized AgNPs present in the hydrogels were
characterized by Fourier-transform infrared spectroscopy, UV-visible spectroscopy, X-ray diffraction, and scanning electron
microscopy. Transmission electron microscopy and dynamic light scattering revealed the AgNPs to have a mean size of
approximately 5–8 nm. The Lys-encapsulated hydrogel silver nanocomposite exhibited excellent antibacterial activity toward
both Gram-positive and Gram-negative bacteria, which was superior to that of hydrogel silver nanocomposites produced by
sodium borohydride reduction. The results highlight the potential of the Lys-mediated production of silver nanocomposites for
antibacterial wound dressing applications.
Keywords
Lysozyme Hydrogel Silver nanoparticles Antibacterial activity Wound dressing.References
No references available for this article.
Citation
G. Viswanatha Reddy, K. Madhusudana Rao, K. S. V. Krishna Rao*, Chang-Sik Ha*. Synthesis of Silver Nanocomposite Hydrogel from Lysozyme-Mediated Poly(acrylamide) for the Inactivation of Pathogenic Bacteria . J Appl Pharm Sci. 2018; 6(3):163-170.