Abstract

Amberlite infrared (IR)-120 catalyzed synthesis of 6-aryl-5H-quinazolino[4,3-b]quinazolin8(6H)-one derivatives was reported.
2-(2-aminophenyl)quinazolin-4(3H)-ones on reaction with aromatic aldehydes using Amberlite IR-120 resin yielded a variety
of 6-aryl-5H-quinazolino[4,3-b]quinazolin-8(6H)-one derivatives in good to excellent yields. This method has the advantages
of high yields, easy purification and having mild reaction condition. All the synthesized compounds were evaluated for their
anti-proliferative properties in vitro against cancer cell lines, and several compounds were found to be active.