Biological Activity and Variation of Toxicity of Probenecid in Diverse Solvent Systems Probed by Physicochemical Investigation
Niloy Roy, Koyeli Das, Uttara Dey Bhowmick, Soumen Bhattacharjee, Mahendra Nath Roy*
DOI: 10.22607/IJACS.2018.604004
Volume 6, Issue 4 | Pages: 193-199
Abstract
Probenecid has an extended and storied history in medicine that has been characterized by unexpected usefulness and a very
benign toxicity profile. The solubility of probenecid (PB) in water (H2O), ethanol (EtOH), ethoxyethanol, ethyl acetate (EtOAc),
and ({ethyl acetate (EtOAc) + ethanol (EtOH)}, {ethyl acetate + ethoxy ethanol} binary co-solvent mixtures) was determined
at three different temperatures from T = 298.15 K to T = 308.15 K was determined consecutively to open further fields in the
clinical treatments.
Keywords
Ion-solvent interaction Cytotoxicity Probenecid Ethyl acetate-ethoxy-ethanol FluorescenceReferences
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Citation
Niloy Roy, Koyeli Das, Uttara Dey Bhowmick, Soumen Bhattacharjee, Mahendra Nath Roy*. Biological Activity and Variation of Toxicity of Probenecid in Diverse Solvent Systems Probed by Physicochemical Investigation. J Appl Pharm Sci. 2019; 6(4):193-199.