In Vitro Hormone-Sensitive Lipase Inhibitory And Antioxidant Activities, Phytochemical Screening Of Methanolic Extract, And Its Fractions From Solanum Nigrum
Jeelan Basha Shaik, Ramakrishnan Ranjani, Kandrakonda Yalamanda Rao, Damu Amooru Gangaiah*
DOI: 10.22607/IJACS.2018.604009
Volume 6, Issue 4 | Pages: 223-229
Abstract
Solanum nigrum (SN) Linn. (Solanaceae) methanolic extract and its fractions were investigated for their health-benefit properties,
in particular with respect to antioxidant activity and inhibitory ability toward key enzyme hormone-sensitive lipase (HSL)
with impact in diabetes and obesity. The SN chloroform fraction was the most promising in regard to the antioxidant effects,
namely in the scavenging capacity of the free radicals 2,2-diphenyl-1-picrylhydrazyl and 2,2-azinobis[3-ethylbenzthiazoline]-6-
sulfonic, as well as the most effective inhibitor of HSL. In addition, the phytochemical screening of the active fraction was also
carried out. These results revealed that chloroform fractions of the methanolic extract of SN bears strong HSL inhibitory and
antioxidant properties; it can, therefore, be used as a potential antidiabetic herb.
Keywords
Hormone sensitive lipase Solanum nigrum Linn Type 2 diabetes mellitus.References
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Citation
Jeelan Basha Shaik, Ramakrishnan Ranjani, Kandrakonda Yalamanda Rao, Damu Amooru Gangaiah*. In Vitro Hormone-Sensitive Lipase Inhibitory And Antioxidant Activities, Phytochemical Screening Of Methanolic Extract, And Its Fractions From Solanum Nigrum. J Appl Pharm Sci. 2019; 6(4):223-229.