Abstract

A versatile and green synthetic protocol has been developed for the synthesis of substituted quinazolinone and spiroquinazolinone
heterocycles effectively through a combined surfactant-mediated system. The use of surfactant, water as reaction medium, room
temperature, high yield, and ease of purification made the process very effective and eco-friendly in nature. To demonstrate the
wide scope of the reaction, isatoic anhydride and isatin are used as reactants in different sets of reactions that lead to the formation
of quinazolinones and spiroquinazolinones. Atotal of 12 derivatives have been prepared and characterized by all the spectroscopic
data. The developed protocol presents a better and environmentally efficient methodology to get these heterocycles.