Abstract

A green, efficient, and solvent-free method for the Knoevenagel condensation has been developed using a novel biocompatible catalyst system comprising phenylalanine and sodium acetate under one-pot grinding conditions. The catalyst promotes C=C bond formation between various aromatic aldehydes and active methylene compounds such as malononitrile and dimethyl malonate with excellent yields and short reaction times. This mechanochemical approach eliminates the use of hazardous organic solvents and harsh reaction conditions, aligning well with green chemistry principles. The method offers a simple work-up procedure, good functional group tolerance, and ability of the catalyst.