Abstract

In this work, synthesis of four novel flavones (2a-d) and four pyrazoline derivatives (3a-d) have been described.
2-hydroxy chalcones (1a-d) underwent oxidative cyclization with I2-dimethyl sulfoxide to afford 2a-d, whereas
condensation cyclization of the same chalcones with hydrazine hydrate in ethanol yielded 3a-d. Chalcones required
were synthesized by Claisen-Schmidt condensation of substituted 2- hydroxy acetophenones (a-d) and benzyloxy
benzaldehyde (1). The structures of the title compounds 2a and 3a were characterized by chemical reactions,
elemental analysis, and spectral methods such as IR, 1H NMR and mass spectra. The synthesized compounds
were evaluated for in-vitro antibacterial and antioxidant activities against standard. The zone of inhibition for
some of the newly synthesized compounds showed notable antibacterial activity against selected bacterial strains
compared with chloramphenicol. Significant antioxidant activities were also shown by flavones and pyrazolines.