Synthesis of (4-Bromo-3-Fluorophenyl)(Pyrimidin-5-yl)Methanol and their Transition Metal Complexes, Spectral, X-ray Powder Diffraction, Cytotoxicity, Molecular Docking, and Biological Evaluation
R. Mohammed Shafeeulla, Ganganaik Krishnamurthy*, Halehatti S. Bhojynaik, T. Manjuraj1, Subba Poojari
DOI: 10.22607/IJACS.2017.504007
Volume 5, Issue 4 | Pages: 268-279
Abstract
The article deals with a study of a new series of transition metal complexes such as Co(II), Ni(II), Cu(II), and
Zn(II) with pyrimidine-based ligand (4-bromo-3-fluorophenyl)(pyrimidin-5-yl)methanol; the novel ligand has been
synthesized through Barbier-type reaction and structurally characterized by 1H nuclear magnetic resonance,
infrared, ultraviolet-visible, and powder X-ray powder diffraction (XRD) spectral techniques. The powder
XRD studies reveal that all complexes are in crystalline nature. The cytotoxic activity of the complexes and the
uncoordinated ligand against human breast cancer (MCF-7) and chronic myelogenous leukemia cell line (K-562)
exhibits good viability in the range of 52.11-66.23% at the concentration >100-110 μg/mL as compared to the
inhibition in the untreated cells. The result of antibacterial activity revealed that the complexes of cobaltand
copper are active against the studied bacteria and fungi, and the cytotoxicity studies are correlated with the
computational docking analysis.
Keywords
Barbier reaction Lithium metal Sonochemistry.References
No references available for this article.
Citation
R. Mohammed Shafeeulla, Ganganaik Krishnamurthy*, Halehatti S. Bhojynaik, T. Manjuraj1, Subba Poojari. Synthesis of (4-Bromo-3-Fluorophenyl)(Pyrimidin-5-yl)Methanol and their Transition Metal Complexes, Spectral, X-ray Powder Diffraction, Cytotoxicity, Molecular Docking, and Biological Evaluation. J Appl Pharm Sci. 2018; 5(4):268-279 .