Schiff Base-Copper(II) Complexes: Synthesis, Spectral Studies and Anti-tubercular and Antimicrobial Activity
S. Syed Tajudeen, Geetha Kannappan*
DOI:
Volume 4, Issue 1 | Pages: 40-48
Abstract
The present study deals with the synthesis, spectral characterization of Schiff base complexes of isoniazid,
pyrazinamide an anti-tubercular drug, and benzhydrazide, nicotinohydrazide. Metal selected for complexation is
copper. The complexes have been suitably synthesized and isolated in pure powdered form. Analytical data agree
with the compositions [L2CuClO4]ClO4. Molar conductance values suggesting that they were 1:1 electrolytic
nature. The tentative structure assigned to the complexes on the basis of stoichiometry and analytical data were
further supported by spectral studies viz.; Fourier transform infrared, magnetic susceptibility, electronic spectra,
cyclic votammetry, liquid chromatography-mass spectrometry spectra, and electron paramagnetic resonance
studies. A preliminary attempt has also been made to compare the potencies of metal complexes with parent drug.
The copper(II) complexes are giving encouraging results.
Keywords
Schiff base Isoniazid Pyrazinamide Benzhydrazide Nicotinohydrazide Anti-tubercular activity Antimicrobial activity.References
No references available for this article.
Citation
S. Syed Tajudeen, Geetha Kannappan*. Schiff Base-Copper(II) Complexes: Synthesis, Spectral Studies and Anti-tubercular and Antimicrobial Activity. J Appl Pharm Sci. 2016; 4(1):40-48.