Abstract

The ultraviolet (UV) spectrophotometric method has been developed for the determination of paliperidone
palmitate (PP) in the pharmaceutical formulation using bromocresol green (BCG) and tropeolin-oo sol (TPOO)
methods. The PP chemically named as, (9RS)-3-[2-[4-(6-fluoro-1,2,benzisoxazol-3-yl)piperidin-1-yl]ethyl]-
2-methyl4-oxo-6,7,8,9-tetrahydro-4H-pyridol [1,2-a] pyrimadin-9-ylhexadecanoate is an antipsychotic drug
used in the treatment of schizophrenia. It works by helping to restore the balance of certain natural chemicals
(neurotransmitters) in the brain. The chemical and reagents were prepared for BCG and TPOO methods. Blank
solution and sample solution were prepared for the spectrophotometric metyhods. The blank and sample solutions
were prepared with chloroform. PP Obey’s Beer’s law between the range of 0-200 mg ml−1. PP solution in the
BCG and TPOO shows as the wavelength of maximum absorbance at 420 nm and 410 nm, respectively. The
orange color solution is obtained. The calibration graphs constructed at their wavelength of determination were
found to be linear for UV spectrophotometric method.