Abstract

In this study, conventional and microwave assisted synthesis of 5-phenyl-2-substituted-1,3,4-oxadiazole derivatives
have been reported. The structures of synthesized compounds have been confirmed by Fourier transform infrared,
1H nuclear magnetic resonance (NMR), 13CNMR, and mass spectroscopic methods. The title compounds were
screened for antimicrobial and antioxidant activity followed by molecular docking studies. The compounds 3e
and 3g were endowed with a high antibacterial activity when compared with standard antibacterial drugs and
among docked compounds; the compound 3 g showed the best docking with 2-XCT protein. The antioxidant
results revealed that the compounds exhibit dose-dependent antioxidant activity. Compounds 3a, 3b, 3c, 3e, and
3f have potential radical scavenging, while compounds 3a, 3b, 3c, 3h, and 3j have potential metal chelating
ability as comparable with the standard used.