Abstract

A series of 2-(2-substituted)-5-phenyl-1,3,4-oxadiazole 3(a-c) and 3,6-iphenyl[1,2,4]triazole[3,4-][1,3,4]
thiadiazole 6(a-g) derivatives were synthesized. Compounds 3(a-c) were synthesized by the reaction of substituted
benzohydrazide with different benzoic acids in the presence of POCl3. Cyclocondensation of the SH and NH2
groups of compound 5(a-b) with appropriate benzoic acid derivatives in the presence of phosphoryl chloride
gave 3,6-diphenyl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives 6(a-g). The synthesized compounds were
screened for their antimicrobial and antioxidant activities. Among the tested, compounds 6a and 6d displayed
very good antibacterial activity. Compound 6a showed good antifungal activity against all the fungal strains.
Compound 6g displayed good activity against Aspergillus flavus. Compounds 6a and 6d showed promising
2,2-diphenylpicrylhydrazyl radical scavenging activity.