Abstract

Mn(II) complex of 1-(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)octadecan-1-one (HMPPO) was synthesized
by the reaction of HMPPO with MnCl2.4H2O. The color, yield, melting point, and conductance of the complex
were determined. The complex was characterized based on elemental analysis, infrared spectrum, 1H nuclear
magnetic resonance (NMR), and 13C NMR. The coordination sites of the HMPPO ligand were through C=O,
C=N, OH, and H2O. The molecular formula Mn(HMPPO).H2O was proposed for the complex. A tetrahedral
geometry was suggested for the complex. Furthermore, the biological activities of the Mn(HMPPO).H2O against
benign prostatic hyperplasia (BPH) cells were studied. Mn(HMPPO).H2O reduced prostate-specific antigen
(PSA) significantly (p<0.05) relative to the hormone control (HC) group. Mn(HMPPO).H2O arrested the growth
of prostatic cells in the test groups leading to a decreased secretion of prostatic acid phosphatase in the prostatic
cells. There was a significant increase (p<0.05) in the relative prostate weight of “HC” group compared to
Mn(HMPPO).H2O. The result of this study showed that Mn(HMPPO).H2O has an inhibitory effect on the
development of BPH.