Abstract

A new series having quinoline, pyrazoline/isoxazoline, and benzotriazole moiety in a single molecule frame have
been synthesized by mixture of 2-(1H benzo[d][1,2,3]triazol-1-yl)-6-substituted quinoline-3-carbaldehyde 1
and substituted acetophenone 2 in ethanolic sodium hydroxide using ultrasound irradiated for 10-20 min at
50°C. After that add hydroxylamine hydrochloride/hydrazine hydrate and further irradiated for 5-15 min at 50°C
to form desired compounds 3a-r. The synthesized compounds confirmed by IR, 13C NMR, 1H NMR, and mass
spectroscopic methods. All the synthesized compounds were evaluated for antimicrobial activity. From all the
compounds, 3b, 3h, and 3n have shown more activity as compared to standard drugs.