Abstract

The blend microspheres based on soy protein isolate (SPI) and guar gum (GG) were prepared by solution
blending and then cross-linked with Ca2+ ion, and their function as drug carrier was explored as well. The effects
of SPI/GG blend composition on the structures of microspheres were studied. Fourier transform infrared results
suggested that miscibility was driven by strong hydrogen bonding. Morphological properties of the microspheres
were studied by scanning electron microscopic analysis. Thermal properties and crystallinity of the microspheres
were characterized using differential scanning calorimetry and X-ray diffraction techniques, respectively. The
controlled release function of the complex microspheres was verified using tolterodine as a model drug, that is,
the swelling and drug release were affected by (pH-7.4) condition. Dissolution experiments were performed at
37°C in phosphate buffer solution (pH-7.4).