Design, Synthesis and Characterization of Biodegradable Sorbitol Elastomers with Tunable Mechanical and Degradation Properties
A. Viswanathan Kavimani, B. Viswanathan Jaisankar
DOI:
Volume 3, Issue 2 | Pages: 192-197
Abstract
In this investigation we have synthesized a family of novel polyesters that are composed of structural units
endogenous to the human metabolism such as Sorbitol, diethylene glycol, and diacids designated as poly (Sorbitol
succinate-co-diethylene glycol succinate) (PSSaDEG), poly (sorbitol adipate-co-diethylene glycol adipate)
(PSAaDEG), poly (sorbitol suberate-co-diethylene glycol suberate) (PSSuDEG) and poly (sorbitol suberate-
co-diethylene glycol sebacate) (PSSeDEG) by catalyst-free melt polycondensation method. The synthesized
pre-polymers were characterized by Fourier transform infrared and 1H and 13C nuclear magnetic resonance
spectra. Mechanical, swelling and degradation studies to evaluate the elastomeric and biodegradable properties.
The results showed that PSADEG behaves like a thermoset and other three polymers PSSDEG, PSSuDEG and
PSSeDEG are elastomeric in nature. Material properties of these polymers can be tuned by altering the diacid
monomer and this study consistently proved that these elastomers can be used as scaffold material in the future
after proving the non-toxic nature by cytotoxicity studies.
Keywords
Catalyst free melt polycondensation Sorbitol Mechanical Swelling and degradation studies.References
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Citation
A. Viswanathan Kavimani, B. Viswanathan Jaisankar. Design, Synthesis and Characterization of Biodegradable Sorbitol Elastomers with Tunable Mechanical and Degradation Properties. J Appl Pharm Sci. 2015; 3(2):192-197.