Abstract

The chronopharmacotherapy drug delivery system is widely used for treatment of diseases occurs due to circadian
changes in the body. This system is aims to release drugs at a programmed pattern i.e., at appropriate time
and/or at appropriate site of action. In this investigation, a novel oral pulsatile drug delivery system (PDDS)
based on a core-in-cup dry coated tablet. The core containing eprosartan mesylate as a bioactive compound was
prepared by direct compression method and evaluated for thickness, hardness, weight variation and friability.
The impermeable coating cup consisted of hydrophobic polymer of cellulose acetate propionate, and the top
cover layer of hydrophilic swellable materials (sodium alginate, hydroxypropyl methylcellulose [HPMC] K4M,
sodium carboxy methylcellulose) were used in different concentration. The tablets prepared were evaluated for
micromeritic properties, hardness, thickness, weight variation, friability, drug content uniformity and in-vitro
drug release study. The drug-excipients study was carried out by using Fourier transform infrared. From the
obtained results, it was found that the order of sustaining capacity of pulsatile device is, HPMC K4M >sodium
carboxymethyl cellulose >sodium alginate.