Abstract

Guiera senegalensis is a plant from the Senegalese pharmacopeia, current study dealt with the evaluation of crude extracts of
G. senegalensis leaves antibacterial activity. The phytochemical study was carried out using coloring and precipitation tests.
For the antibacterial evaluation, the minimum inhibitory concentration was determined using the double dilution method of
concentrations expressed as (g/mL). Two strains of bacteria were used: Escherichia coli and Staphylococcus aureus. In terms
of results, phytochemical analysis revealed the presence of polyphenols, flavonoids, alkaloids, and hydrolyzable tannins in all
extracts. However, catchy tannins are absent in the methanolic extract.
On the other hand, sensitivity studies of crude extracts of G. senegalensis leaves showed that E. coli was very sensitive to the
methanolic extract and moderately susceptible to S. aureus. Chloroform extracts also showed significant sensitivity to S. aureus
and less sensitivity to E. coli. However, the cyclohexane extract showed no sensitivity to the bacteria tested. Interestingly, the
antibacterial activity of crude extracts of G. senegalensis leaves showed that the chloroform extract had a bactericidal effect
on S. aureus with an antibacterial power <4 and has a bacteriostatic effect on E. coli. However, the methanol and cyclohexane
extracts had bacteriostatic effects on the strains studied.