Abstract

A series containing nine 3-thienyl chalcones have been synthesized solvent-free crossed aldol condensation of 3-
acetyl thiophene and substituted benzaldehydes. The purities of these synthesized chalcones were checked by
their physical constants and spectral data published earlier in literature. The spectral data such as UV λmax(nm),
infrared ν(cm-1) COs-cis and s-trans, stretches, CH, CH=CH, C=C deformation modes, NMR chemical shifts (δ,
ppm) of vinyl proton, carbon and carbonyl carbon of these chalcones were correlated with Hammett substituent
constants, F and R parameters using single and multi-linear regression analyses. From the results of statistical
analyses the effect of substituents on the above spectral data has been studied.