Abstract

The suggestion that thiosemicarbazones act as iron chelators interfering with DNA synthesis to prevent their
production and copper complexes with aromatic thiosemicarbazones affected the complicated mechanism of
leukemic transformations, lead to a lot of interest in their metal complexation reactions. Provision of additional
donor sites, improve their denticity and utilizing N4 substitution on the ligand have become vital in their
remarkable antitumor, antibacterial, antifungal activities. A novel Anthraquinone N4benzylthiosemicarbazone
Cr (III) complex with a potential to act as an anti-cancer drug has been synthesized and characterized by
spectral methods. Effect of N4-substitution, additional donor sites and complexation on the biological activity of
the ligand has been studied.