Abstract

The purpose of this study is to evaluate Alprazolam effects on blood metabolites, Red Blood Cell (RBC)
membrane and Nitric Oxide (NO) levels on long term use by human volunteers. A total of 16 subjects from
Anantapur District of Andhrapradesh State were taken and divided into two groups of eight subjects each.
Group I served as control (non APZ users) and group II served as test sample (long term APZ users).
Biochemical studies were conducted with plasma and RBC membrane of two groups. Result of this study
revealed that the concentrations of glucose, cholesterol and a lipoprotein LDL-C were decreased, and in
contrast the concentrations of tri-glycerides, lipoproteins (HDL-C & VLDL-C) and nitrates were increased in
plasma of group II when compared with group I. Very slight increased and decreased concentrations of HbA1c
and nitrites were detected in plasma of group II, respectively. Similarly, Studies on RBC membrane were evident
that significant depletion of cholesterol and phospholipids in group II.