Abstract

A simple and highly efficient procedure has been described for the synthesis of 3-bromo-1-phenyl-pyrazole
derivatives. The cyclization of pyrazole ring is carried under microwave irradiation using chloramine-T as
catalyst. The products were obtained in very good yields and characterized by elemental, U.V. Vis, I.R., NMR
and mass spectra. HOMO and LUMO studies were carried by the density functional theory (DFT). Calculations
have been performed at the B3LYP/ 6-31+G(d,p) level of theory. The antimicrobial and antifungal activities of
all compounds have been screened against Bacillus subtillis, Escherichia coli, Aspergillus niger and Candida
albicans.